반응 #1552037

반응 방정식

palmitoyl chloride

N-hydroxysuccinimide

triethylamine

→

N-palmitoyloxy-Succinimide

용매

chloroform

반응 조건

후처리

1. 1
   세척After washed with 500 mL of water three times
2. 2
   건조the resultant solution was dried over magnesium sulfate
3. 3
   농축was then concentrated under reduced pressure
4. 4
   기타to obtain 260.3 g (quant) of a colorless solid

실험 절차

To a solution of 165 mL (0.544 mol) of palmitoyl chloride in 1 L of chloroform while cooled with ice with stirring, 69.8 g (0.598 mol) of N-hydroxysuccinimide was gradually added, and 83.1 mL (0.598 mol) of triethylamine was added dropwise thereto over 30 minutes. The resultant solution was stirred for 30 minutes while cooled with ice and for another 7 hours during which the resultant solution gradually reached room temperature. After washed with 500 mL of water three times, the resultant solution was dried over magnesium sulfate and was then concentrated under reduced pressure to obtain 260.3 g (quant) of a colorless solid.

출처