반응 #1549741

반응 방정식

6-(3-piperazinylpropyl)-3,4-dihydrocarbostyril

p-nitroaniline

potassium carbonate

→

6-{3-[4-(4-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

용매

3-methoxybutanol

반응 조건

후처리

1. 1
   온도refluxed
2. 2
   온도by heating for 5 hours
3. 3
   workup.ADDITIONThen 3 g of activated carbon was added to the reaction mixture
4. 4
   여과filtered with Celite
5. 5
   농축the mother liquor was concentrated under a reduced pressure
6. 6
   기타to obtain a residue
7. 7
   기타The residue was purified by a silica-gel chromatography
8. 8
   기타recrystallized from isopropanol

실험 절차

2.87 Grams of 6-(3-piperazinylpropyl)-3,4-dihydrocarbostyril, 2.0 g of p-nitroaniline, 0.8 g of potassium carbonate and 0.2 g of copper powder were mixed in 80 ml of 3-methoxybutanol and refluxed by heating for 5 hours. Then 3 g of activated carbon was added to the reaction mixture and filtered with Celite, then the mother liquor was concentrated under a reduced pressure to obtain a residue. The residue was purified by a silica-gel chromatography and recrystallized from isopropanol to obtain 0.55 g of 6-{3-[4-(4-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril in yellow needle-like crystals, having the melting point of 189°-192° C.

출처