반응 #1544

반응 방정식

6-ethyl-2-phenyl-4(3H)-pyrimidinone

sodium hydroxide

iodine

→

6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone

수율 94.5%

용매

water

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   여과filtered
3. 3
   기타The white solid collected
4. 4
   기타was dried in a vacuum oven

실험 절차

A mixture of 8.18 g (40.9 mmol) of 6-ethyl-2-phenyl-4(3H)-pyrimidinone, 1.68 g (42.0 mmol) of sodium hydroxide, 10.42 g (41.0 mmol) of iodine and 50 mL of water was heated at 50° C. for 4 h. The mixture was cooled and filtered. The white solid collected was dried in a vacuum oven to leave 12.60 g (75%) of 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone. 1 H-NMR (d6-DMSO) δ 1.25(3H,t), 2.85(2H,q), 7.50(3H,m), 8.15(2H,m).

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