반응 #1543046

반응 방정식

Boc-D-Pal

Benzyl bromide

→

Boc-D-Pal(Bzl) Hydrobromide

수율 85.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타A clear solution resulted
2. 2
   기타A white precipitate formed
3. 3
   workup.WAITTLC after 17 hours showed
4. 4
   workup.STIRRINGstirring
5. 5
   기타continued for a total of 5 days, when
6. 6
   기타The solvent was evaporated under reduced pressure
7. 7
   기타the residue recrystallized from EtOH/ethyl acetate

실험 절차

Boc-D-Pal (1.36 g, 6.0 mmol) was suspended in 60 ml of acetonitrile. Benzyl bromide (about 50 mmol) was added and the mixture was warmed to 50° C. on a water bath. A clear solution resulted, and was stirred at room temperature for 16 hours. A white precipitate formed; TLC after 17 hours showed some starting remaining starting material; stirring continued for a total of 5 days, when the reaction was complete. The solvent was evaporated under reduced pressure, and the residue recrystallized from EtOH/ethyl acetate. Yield: 85%; m.p. 166°-170° C.

출처