반응 #1537885

반응 방정식

4-hydroxyethyl piperidine

N-benzyloxycarbonyl-S-methyl isothiourea

→

title compound

수율 41.0%

1-Benzyloxycarbonylamidino-4-hydroxyethyl piperidine

수율 41.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   기타Evaporation and flash chromatography on silica gel with ethyl acetate

실험 절차

A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

출처