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7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione

choline hydroxide

→

title compound

수율 78.0%

7-Bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione Choline Salt

수율 78.0%

용매

methanol

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후처리

1. 1
   농축The resulting solution was concentrated
2. 2
   기타the solid yellow residue was recrystallized from ethanol

실험 절차

To a suspension of 7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione (0.600g, 1.95 mM) in methanol (20 mL) was added choline hydroxide (0.24 g, 1.98 mM, 45% solution in methanol). The resulting solution was concentrated and the solid yellow residue was recrystallized from ethanol to provide (0.62 g, 78%) the title compound as yellow crystals, mp 227.5°-228.5° C.

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