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8-t-butyl-2-chloromethyl-1,4-dioxaspiro(4,5)decane

potassium phthalimide

potassium phthalimide

→

title compound

수율 101.4%

8-t-butyl-2-(phthalimidomethyl)-1,4-dioxaspiro-(4,5)decane

수율 101.4%

용매

DMF

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후처리

1. 1
   기타prepared
2. 2
   온도heating
3. 3
   기타The solvent was then evaporated in vacuo and toluene (150 ml)
4. 4
   workup.ADDITIONwas added
5. 5
   여과After filtration from insoluble material the organic phase
6. 6
   세척was washed two times with brine (100 ml)
7. 7
   건조dried (MgSO4)
8. 8
   기타evaporated in vacuo
9. 9
   기타The resulting residue (22 g) was purified by flash chromatography on silica (toluene/ethylacetate 3:1)

실험 절차

A mixture of 8-t-butyl-2-chloromethyl-1,4-dioxaspiro(4,5)decane (10 g, 40 mmol) (prepared as described in EP 281842; see also the references cited in this document for-related compounds), potassium phthalimide (8.9 g, 48 mmol) and a catalytic amount of tetra-n-butyl ammonium iodide in DMF (80 ml) were heated to 120° C. for 3 hours. Additional potassium phthalimide (2.8 g, 16 mmol) was then added and heating was continued for 6 hours. The solvent was then evaporated in vacuo and toluene (150 ml) was added. After filtration from insoluble material the organic phase was washed two times with brine (100 ml), dried (MgSO4) and evaporated in vacuo. The resulting residue (22 g) was purified by flash chromatography on silica (toluene/ethylacetate 3:1) yielding the title compound as light yellow crystals (14.5 g, Fp. 97°-115° C.).

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