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7-Chloro-2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-c]pyridine

7-chloro-2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-c]pyridine

1,2,3,4-tetrahydroisoquinoline

→

titled compound

2-(2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-1,2,3,4-tetrahydroisoquinoline

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후처리

1. 1
   온도cooled to room temperature
2. 2
   기타purified with silica gel column chromatography

실험 절차

7-Chloro-2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-c]pyridine (418 mg) prepared in Step 1 was added to 1,2,3,4-tetrahydroisoquinoline (3 ml). The reaction mixture was stirred overnight at 140° C., cooled to room temperature, and then purified with silica gel column chromatography to give 440 mg of the titled compound as pale yellow oil.

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