반응 #1528932

반응 방정식

dioxane

sodium hydroxide

3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-benzonitrile

→

title compound

3-(4-Methyl-1-piperazinyl)-5-(trifluoromethyl)-benzoic acid

용매

water

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   기타the mixture is evaporated to dryness under reduced pressure
3. 3
   workup.ADDITIONThe resulting residue is treated with water
4. 4
   여과The precipitate is filtered off
5. 5
   추출the filtrate extracted twice with n-butanol
6. 6
   기타The combined organic extracts are evaporated

실험 절차

A mixture consisting of 50 mL dioxane, 25 mL water and 18.75 mL 2M aqueous sodium hydroxide solution is added to 3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-benzonitrile (2.69 g, 10 mmol) and the reaction mixture shaken for 16 hours at 95° C. After cooling, the mixture is evaporated to dryness under reduced pressure. The resulting residue is treated with water, the pH adjusted to ˜5-6 with 2M hydrochloric acid. The precipitate is filtered off and the filtrate extracted twice with n-butanol. The combined organic extracts are evaporated to yield the title compound as a solid.

출처