반응 #1528382

반응 방정식

HCl

NaOH

4-hydroxy cinnamic acid

6-bromo-1-hexanol

→

4-((6-hydroxyhexyl)oxy)cinnamic acid

수율 78.7%

용매

water

methanol

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타the reaction
3. 3
   온도the mixture was cooled to normal temperature
4. 4
   여과the obtained precipitants were filtered

실험 절차

A solution of 4.4 g of NaOH in 20 ml of distilled water was added to a solution of 7.5 g of 4-hydroxy cinnamic acid in methanol, 0.02 g of Kl was added thereto, and then 10.0 g of 6-bromo-1-hexanol was slowly added dropwise for reaction at 65° C. for 24 hours. 100 ml of distilled water was added thereto to complete the reaction, and then the mixture was cooled to normal temperature. A 10% aqueous HCl solution was added thereto, and the obtained precipitants were filtered to obtain 9.5 g of 4-((6-hydroxyhexyl)oxy)cinnamic acid. (Yield: 60%)

출처