반응 #1526438

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2,3-dibromothiophene

butyllithium

sulfur

methyl chloroacetate

3-bromo-2-thienylthio-acetic acid

→

(3-Bromo-2-thienylthio)-acetic Acid

수율 76.0%

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후처리

1. 1
   기타After chromatography on silica gel (eluent: hexane/acetone/acetic acid = 93:5:2), the product is obtained as a non-crystallizing oil
2. 2
   기타yields correct elementary analyses for C, H, S, and Br

실험 절차

The compound is prepared analogously to Example 10 by saponification of the crude methyl ester of (3-bromo-2-thienylthio-acetic acid prepared with a 76% yield from 2,3-dibromothiophene, butyllithium, sulfur, and methyl chloroacetate. After chromatography on silica gel (eluent: hexane/acetone/acetic acid = 93:5:2), the product is obtained as a non-crystallizing oil. The compound shows the physiochemical data to be expected (IR, NMR spectrum) and yields correct elementary analyses for C, H, S, and Br.

출처