반응 #1524

반응 방정식

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   추출the resultant mixture was extracted with ether
3. 3
   세척washed with water, which
4. 4
   세척was further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   세척washed again with water
7. 7
   농축The reaction product was concentrated
8. 8
   기타separated by colomun chromatography

실험 절차

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

출처