반응 #1523

반응 방정식

LiAlH4

4'-decyloxy-4-biphenylcarboxylic acid

→

4-hydroxymethyl-4'-decyloxybiphenyl

용매

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   workup.ADDITIONTo the mixture was dropwise added a solution
2. 2
   기타prepared
3. 3
   workup.STIRRINGwhich was then continuously stirred for 5 days
4. 4
   기타the consumption of the raw material by TLC
5. 5
   workup.ADDITIONto the resultant mixture was added 40 ml of water
6. 6
   workup.ADDITIONfurther added concentrated hydrochloric acid until the aqueous phase
7. 7
   workup.STIRRINGwas approximately homogenized
8. 8
   추출The resultant solution was extracted with diethyl ether
9. 9
   기타dried

실험 절차

0.81 g (21.34 mmol) of LiAlH4 was introduced into 40 ml of diethyl ether and stirred. To the mixture was dropwise added a solution, prepared by introducing 1.71 g (5.06 mmol) of 4'-decyloxy-4-biphenylcarboxylic acid obtained in the first stage of Example 11 into 30 ml of diethyl ether, at room temperature over a period of 2 to 3 minutes, which was then continuously stirred for 5 days. After confirming the consumption of the raw material by TLC, to the resultant mixture was added 40 ml of water, and further added concentrated hydrochloric acid until the aqueous phase was approximately homogenized. The resultant solution was extracted with diethyl ether and dried, to obtain 4-hydroxymethyl-4'-decyloxybiphenyl.

출처