반응 #1519121

반응 방정식

TMSCl

1H-1,2,3-triazole

→

TMS-triazole

용매

benzene

benzene

반응 조건

후처리

1. 1
   기타Reaction mixture
2. 2
   기타The resultant precipitate is removed by filtration
3. 3
   세척washed thoroughly with dry benzene
4. 4
   농축The filtrate is gently concentrated
5. 5
   기타to avoid evaporating the highly volatile product

실험 절차

To a solution of 1H-1,2,3-triazole (4.98 g, 72.10 mmol, 1 equiv.) in dry benzene (145 mL) at rt under nitrogen, is added TEA (11.05 mL, 79.31 mmol, 1.1 equiv.) followed by the dropwise addition of TMSCl (9.15 mL, 72.10 mmol, 1 equiv.). A white precipitate develops. Reaction mixture is stirred at rt under nitrogen for 1 hour. The resultant precipitate is removed by filtration and washed thoroughly with dry benzene. The filtrate is gently concentrated to avoid evaporating the highly volatile product to give a quantitative yield of TMS-triazole with a trace of benzene.

출처