반응 #1519120

반응 방정식

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

용매

DCM

반응 조건

후처리

1. 1
   온도is heated
2. 2
   온도to reflux under nitrogen for 20 minutes
3. 3
   농축concentrated in vacuo
4. 4
   농축concentrated

실험 절차

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

출처