반응 #1519118

반응 방정식

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

용매

DCM

2,2-dimethoxypropane

반응 조건

후처리

1. 1
   세척washed with brine
2. 2
   건조dried (Na2SO4)
3. 3
   기타purified by silica gel chromatography

실험 절차

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

출처