반응 #1519117

반응 방정식

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

용매

MeOH

water

반응 조건

후처리

1. 1
   기타the MeOH is removed
2. 2
   기타the crude reaction
3. 3
   추출extracted with EtOAc (3×50 mL)
4. 4
   건조The combined organic layers are dried (Na2SO4)
5. 5
   농축concentrated

실험 절차

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

출처