반응 #1519107

반응 방정식

ammonium chloride

4-chloro-2-cyanopyridine

sodium methoxide

→

2-amidino-4-chloropyridine hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   온도refluxing
2. 2
   기타The volatile components are then removed in vacuo

실험 절차

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

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