반응 #1514230

반응 방정식

hydrochloric acid

sodium hydroxide

methyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)nicotinate

→

title compound

수율 52.0%

6-(1-(tert-Butoxycarbonyl)piperidin-4-yl)nicotinic acid

수율 52.0%

용매

ethanol

반응 조건

후처리

1. 1
   추출The aqueous layer was extracted with ethyl acetate
2. 2
   세척The combined organic layer was washed with a saturated saline solution
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   기타The drying agent was separated by filtration
5. 5
   농축the filtrate was concentrated under vacuum

실험 절차

A 2 M sodium hydroxide solution (20 mL) was added to a solution of methyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)nicotinate described in Production Example 28-2 (1.07 g, 3.32 mmol) in ethanol (5 mL), and the mixture was stirred for 1 hour. 2 M hydrochloric acid was added to the reaction liquid at 0° C. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration and then the filtrate was concentrated under vacuum to obtain the title compound (534 mg, 52%).

출처