반응 #1513

반응 방정식

hydrochloric acid

4'-hydroxybiphenyl-4-carboxylic acid

n-decyl bromide

potassium hydroxide

sodium iodide

potassium hydroxide

→

4'-decyloxybiphenyl-4-carboxylic acid

수율 6.0%

용매

water

water

ethanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도the mixture was further heated
3. 3
   온도under reflux for 2 hours
4. 4
   온도to cool up to room temperature
5. 5
   기타The deposited product was separated by filtration
6. 6
   workup.DISSOLUTIONdissolved in acetone
7. 7
   온도with heating
8. 8
   여과followed by filtration
9. 9
   농축The resulting filtrate was concentrated

실험 절차

A mixture of 21.4 g (0.1 mol) of 4'-hydroxybiphenyl-4-carboxylic acid, 33.15 g (0.15 mol) of n-decyl bromide, 13.20 g (0.2 mol) of 85% potassium hydroxide, 1.05 g (7 mmol) of sodium iodide, 500 ml of ethanol and 100 ml of distilled water was heated under reflux at 100° C. for 12 hours. After 40 ml of 25% potassium hydroxide was added, the mixture was further heated under reflux for 2 hours. After allowing the reaction system to cool up to room temperature, the reaction mixture in cold water was acidified with 36% hydrochloric acid. The deposited product was separated by filtration and dissolved in acetone with heating, followed by filtration. The resulting filtrate was concentrated to obtain 1.97 g (6 mmol) of 4'-decyloxybiphenyl-4-carboxylic acid.

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