반응 #1510

반응 방정식

potassium hydroxide

1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid

benzyl bromide

potassium hydroxide

hydrochloric acid

→

1,2,3,4-tetrahydro-6-benzyloxynaphthalene-2-carboxylic acid

수율 92.8%

용매

water

ethanol

water

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도by heating
3. 3
   온도under reflux at that temperature for 2 hours
4. 4
   온도to cool up to room temperature
5. 5
   여과The resulting deposited product was filtered
6. 6
   기타recrystallized from toluene

실험 절차

A mixture of 10.60 g (50 mmol) of 1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid, 12.85 g (75 mmol) of benzyl bromide, 6.6 g (100 mmol) of 85% potassium hydroxide, 0.525 g (3.5 mmol) of sodium iodide, 200 ml of ethanol and 25 ml of distilled water was heated under reflux at 100° C. for 12 hours. To this reaction mixture was added 50 ml of 10% potassium hydroxide, followed by heating under reflux at that temperature for 2 hours. After allowing the reaction system to cool up to room temperature, the reaction mixture in cold water was acidified with 36% hydrochloric acid. The resulting deposited product was filtered, and recrystallized from toluene to obtain 13.08 g (46.4 mmol) of 1,2,3,4-tetrahydro-6-benzyloxynaphthalene-2-carboxylic acid.

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