반응 #1509921

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Potassium carbonate

thiophene-2-thiol

1,2-dibromoethane

→

2-(2-bromo-ethylsulfanyl)-thiophene

수율 95.0%

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후처리

1. 1
   기타Then potassium carbonate is removed by filtration
2. 2
   농축the mother liquid is concentrated
3. 3
   기타to give a crude that
4. 4
   기타is purified by column chromatography (silica gel, eluent: cyclohexane 100%)

실험 절차

Potassium carbonate (2.50 g, 18.07 mmol, 2.1 eq) is added at room temperature to a stirred solution of thiophene-2-thiol (813 μL, 8.61 mmol, 1.0 eq) in 1,2-dibromoethane (10 mL) and the resulting mixture is stirred at 78° C. for 3 hours. Then potassium carbonate is removed by filtration and the mother liquid is concentrated to give a crude that is purified by column chromatography (silica gel, eluent: cyclohexane 100%) to afford 2-(2-bromo-ethylsulfanyl)-thiophene as a light yellow oil (1.86 g, 95% yield).

출처