반응 #1509609

반응 방정식

compound

5-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-2-(4,7,10-trisethoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)pentanoic acid benzyl ester

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product

수율 138.3%

5-Amino-2-(4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododec-1yl)pentanoic acid

수율 138.3%

용매

hydrochloric acid

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   여과filtration
3. 3
   농축the filtrate is concentrated
4. 4
   기타purified over silanized silica (elution with water)
5. 5
   기타After evaporation under reduced pressure
6. 6
   세척the product is washed with ether

실험 절차

A solution of 54 g of compound obtained in stage 2 (64 ml) in 37% hydrochloric acid (1.81) is refluxed overnight in a 5-liter reactor. After cooling and filtration, the filtrate is concentrated and purified over silanized silica (elution with water). After evaporation under reduced pressure, the product is washed with ether. 45 g of product are obtained in the form of a white solid. The product is desalified by passing it over OH resin. 30 g of product are isolated in the form of white crystals (yield 100%).

출처