반응 #1509597
ord-a15aac5b07ea49c6bd015a4ccf3331e2
반응 방정식
dimethylamine
2-Chloro-6-methyl-isonicotinic acid
DIPEA
TBTU
→
title compound
2-Chloro-6,N,N-trimethyl-isonicotinamide
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with EtOAc
- 2기타The organic layer was separated
- 3기타dried
- 4농축concentrated in vacuum
실험 절차
To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)