반응 #1509593

반응 방정식

3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-benzoic acid ethyl ester

LiAlH4

→

title compound

수율 33.7%

[3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-methanol

수율 33.7%

용매

THF

THF

반응 조건

후처리

1. 1
   workup.ADDITIONThe reaction mixture was poured onto ice-water
2. 2
   추출extracted into EtOAc
3. 3
   기타The organic layer was separated
4. 4
   기타dried
5. 5
   농축concentrated in vacuum

실험 절차

To a solution of 3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-benzoic acid ethyl ester (250 mg) in THF (5 ml) at 0° C. was added pre-cooled 1M LiAlH4 solution in THF (2 ml) dropwise. This was stirred for 3 h. The reaction mixture was poured onto ice-water and extracted into EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash chromatography (100:0 to 95:5 gradient DCM:MeOH) afforded the title compound (70 mg).

출처