반응 #1509592

반응 방정식

3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester

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title compound

수율 72.5%

3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-benzoic acid ethyl ester

수율 72.5%

용매

EtOAc ethanol

반응 조건

후처리

1. 1
   기타was hydrogenated at 20° C.
2. 2
   기타After reaction completion
3. 3
   여과the mixture was filtered
4. 4
   농축the filtrate concentrated in vacuum

실험 절차

A solution of 3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester (6.5 g) in EtOAc:ethanol (1:1, 320 ml) was hydrogenated at 20° C. and 50 psi with 10% Pd/C (750 mg). After reaction completion, the mixture was filtered and the filtrate concentrated in vacuum to give the title compound (4.2 g). Rt=1.21 min (method D).

출처