반응 #1509584

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1-Cyclohexyl-3-(3-nitro-benzyl)-urea

DMF

→

title compound

수율 84.1%

1-(3-Amino-benzyl)-3-cyclohexyl-urea

수율 84.1%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONUnder stirring aqueous hydrazine solution (2.5 ml, 80%) was added
2. 2
   여과filtered
3. 3
   기타The solution was evaporated i.v

실험 절차

1-Cyclohexyl-3-(3-nitro-benzyl)-urea (4 g) was suspended in ethanol (70 ml) and Raney nickel (2 g) was added. Under stirring aqueous hydrazine solution (2.5 ml, 80%) was added. DMF was added (50 ml) and the reaction mixture was stirred for additional 2 h and filtered. The solution was evaporated i.v. affording the title compound (3 g, Rf=0.43 DCM/ethanol 19:1).

출처