반응 #1505860

반응 방정식

7-[3-[5-(1,3-dioxolan-2-yl)thien-2-yl)-2-propenyl]hexahydro-1H-azepin-2-imine, monohydrochloride

triethylamine

2-(5-bromo-2-thienyl)dioxolane

tri-o-tolylphosphine

→

7-[3-[5-(1,3-dioxolan-2-yl)thien-2-yl]-2-propenyl]hexahydro-1H-azepin-2-one

용매

acetonitrile

반응 조건

실험 절차

7-[3-[5-(1,3-dioxolan-2-yl)thien-2-yl)-2-propenyl]hexahydro-1H-azepin-2-imine, monohydrochloride ##STR199## 198 A) The Isomer B title material of Example 18 in acetonitrile is coupled to 2-(5-bromo-2-thienyl)dioxolane in the presence palladium acetate, tri-o-tolylphosphine, and triethylamine by the method of Example 32 to provide 7-[3-[5-(1,3-dioxolan-2-yl)thien-2-yl]-2-propenyl]hexahydro-1H-azepin-2-one as primarily the E isomer.

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