반응 #1502148

반응 방정식

2-cetylcyclopentane-1,3-dione

6-m-methoxyphenylhex-1-en-3-one

→

2-cetyl-2-(6-m-methoxyphenyl-3-oxohexyl)-1,3-cyclopentanedione

수율 73.7%

용매

potassium hydroxide

반응 조건

후처리

1. 1
   온도Reflux
2. 2
   온도cool
3. 3
   workup.DISSOLUTIONDissolve the residue
4. 4
   기타obtained
5. 5
   기타after removal of solvent under reduced pressure
6. 6
   workup.ADDITIONin a mixture of benzene (50 cc) and ether (50 cc)
7. 7
   세척wash the solution in turn with sodium carbonate solution, 10% aqueous sulfuric acid and water
8. 8
   기타Remove the solvent
9. 9
   기타by evaporation under reduced pressure

실험 절차

Reflux a mixture of 2-cetylcyclopentane-1,3-dione (10.1 g), 6-m-methoxyphenylhex-1-en-3-one (6.0 g) and 0.02% methanolic potassium hydroxide solution (120 cc) for 26 hours and then cool. Dissolve the residue obtained after removal of solvent under reduced pressure in a mixture of benzene (50 cc) and ether (50 cc), and wash the solution in turn with sodium carbonate solution, 10% aqueous sulfuric acid and water. Remove the solvent by evaporation under reduced pressure to obtain as residue crude 2-cetyl-2-(6-m-methoxyphenyl-3-oxohexyl)-1,3-cyclopentanedione (11.4 g).

출처