반응 #1502
ord-169f88b27a294c15b3d94e8de0e682c6
반응 방정식
Chloromethyl chloroformate
cholesterol
Pyridine
→
3-(Chloromethoxycarbonyl) Cholesterol
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The solution was cooled
- 2온도Heat
- 3기타was produced
- 4기타the reaction gave a clear solution from
- 5세척washed with 0.5M HCl (50 ml) and water (3×25 ml)
- 6기타After treatment with MgSO4, the solution was evaporated to dryness
실험 절차
Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.