반응 #1495571

반응 방정식

diisopropyl azodicarboxylate

[3-(5-methylpyridin-2-yl)phenyl]methanol

6-(3,5-difluorophenyl)-2H-pyridazin-3-one

triphenylphosphine

→

6-(3,5-difluorophenyl)-2-[3-(5-methylpyridin-2-yl)benzyl]-2H-pyridazin-3-one

용매

THF

반응 조건

후처리

1. 1
   기타The mixture is evaporated
2. 2
   기타the residue is chromatographed on a silica gel column with dichloromethane/methanol as eluent

실험 절차

4.2 134 mg (0.66 mmol) of diisopropyl azodicarboxylate are added to a solution of 88 mg (0.44 mmol) of [3-(5-methylpyridin-2-yl)phenyl]methanol, 138 mg (0.66 mmol) of 6-(3,5-difluorophenyl)-2H-pyridazin-3-one and 174 mg (0.66 mmol) of triphenylphosphine in 3.5 ml of THF. The reaction mixture is stirred at room temperature for 18 hours. The mixture is evaporated, and the residue is chromatographed on a silica gel column with dichloromethane/methanol as eluent: 6-(3,5-difluorophenyl)-2-[3-(5-methylpyridin-2-yl)benzyl]-2H-pyridazin-3-one (“A9”) as colourless crystals; ESI 390.

출처