반응 #1493

반응 방정식

methyl 5,5-dimethyl-5,6-dihydro-8-(phenylthio)-naphthalene-2-carboxylate

Compound E18

methyl 5,5-dimethyl-5,6-dihydro-8-(phenylthio)-naphthalene-2-carboxylate

NaOH

→

title compound

5,5-Dimethyl-5,6-dihydro-8-(phenylthio)-naphthalene-2-carboxylic acid

용매

EtOH

THF

반응 조건

후처리

1. 1
   기타was quenched by the addition of 10% aqueous HCl
2. 2
   추출The mixture was extracted with EtOAc
3. 3
   세척the combined organic layers washed with H2O and saturated aqueous NaCl
4. 4
   건조before being dried over Na2SO4
5. 5
   기타Removal of the solvents under pressure

실험 절차

To a solution of methyl 5,5-dimethyl-5,6-dihydro-8-(phenylthio)-naphthalene-2-carboxylate (Compound E18, 300.0 mg, 0.926 mmol) in 4.0 mL of EtOH and 2.0 mL THF was added NaOH (200.0 mg, 5.00 mmol; 5.0 mL of a 1N aqueous solution). After stirring overnight at room temperature the reaction was quenched by the addition of 10% aqueous HCl. The mixture was extracted with EtOAc and the combined organic layers washed with H2O and saturated aqueous NaCl before being dried over Na2SO4. Removal of the solvents under pressure afforded the title compound as a yellow solid.

출처