반응 #1488

반응 방정식

methyl 5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-2-naphthalenecarboxylate

Compound E5

methyl 5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-2-naphthalenecarboxylate

NaOH

→

title compound

5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalene-2-carboxylic acid

용매

EtOH

THF

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   기타quenched with 1M HCl
3. 3
   추출The mixture was extracted with EtOAc
4. 4
   세척the combined organic layers washed with H2O and saturated aqueous NaCl
5. 5
   건조before being dried over MgSO4
6. 6
   기타Removal of the solvents under reduced pressure

실험 절차

To a solution of methyl 5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-2-naphthalenecarboxylate (Compound E5, 430.0 mg, 1.44 mmol) in 3.0 mL of EtOH and 3.0 mL THF was added NaOH (240.0 mg, 6.00 mmol; 3.0 mL of a 2N aqueous solution). The resulting solution was warmed to 35° C. for 6 h, cooled to room temperature and quenched with 1M HCl. The mixture was extracted with EtOAc and the combined organic layers washed with H2O and saturated aqueous NaCl before being dried over MgSO4. Removal of the solvents under reduced pressure afforded the title compound as a pale yellow solid.

출처