반응 #1483109
ord-6e7ebb03776448d4978fb31307373e63
반응 방정식
pamoic acid
NaOH
→
sodium pamoate
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타A second octreotide-pamoate complex was prepared
실험 절차
A second octreotide-pamoate complex was prepared by dissolving pamoic acid (19.4 mg, 0.05 mmol) in 0.4 N NaOH (250 μL) and dioxane (250 μL) to provide a solution of sodium pamoate in dioxane/water (1:1). Octreotide acetate (50 mg, 0.05 mmol) was dissolved in dioxane/water (1:1, 200 μL). The octreotide acetate solution was added drop wise to the sodium pamoate with mixing to provide a light yellow, homogenous solution. This material was lyophilized to dryness providing a light yellow powder (65 mg). The octreotide/pamoate ratio of this preparation was 1.02 as measured by RP-HPLC. These two preparations were used to prepare new PLGA microparticle formulations.