반응 #1483077

반응 방정식

3-(4-benzoylamino-phenylmethyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester

sodium hydroxide

methanol

water

→

3-(4-benzoylamino-phenylmethyl)-1-methyl-1H-indole-5-carboxylic acid

수율 98.0%

용매

THF

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   workup.ADDITIONThe remaining residue was diluted with ethyl acetate (20 mL)
3. 3
   세척washed with 1N HCl (20 mL)
4. 4
   건조The organic layer was dried over MgSO4
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

A solution of 3-(4-benzoylamino-phenylmethyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester (69 mg, 0.17 mmol), sodium hydroxide (21 mg, 0.52 mmol), methanol (3 mL), water (1 mL) and THF (3 mL) was heated to 60° C. for 24 hr. The reaction solution was then cooled to room temperature and concentrated in vacuo. The remaining residue was diluted with ethyl acetate (20 mL) and washed with 1N HCl (20 mL). The organic layer was dried over MgSO4, filtered and concentrated to provide 3-(4-benzoylamino-phenylmethyl)-1-methyl-1H-indole-5-carboxylic acid (64 mg, 98% yield).

출처