반응 #1480177

ord-578e1d3b185b4c7a8c07911e47d23720

반응 방정식

O.O.O=S(=O)([O-])[O-].[Ca+2]
calcium sulfate dihydrate
CNC(C)[C@@H]1CC[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(C)N)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O
gentamicin sulfate
COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1.[Na+]
naproxen sodium salt
→
COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
naproxen

반응물

—
poly-L-lactide
O.O.O=S(=O)([O-])[O-].[Ca+2]
calcium sulfate dihydrate
CNC(C)[C@@H]1CC[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(C)N)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O
gentamicin sulfate
COc1ccc2cc([C@H](C)C(=O)[O-])ccc2c1.[Na+]
naproxen sodium salt

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

A mixture of 1,000.0 mg calcium sulfate dihydrate (Fluka), 250.0 mg poly-L-lactide (M-10,000 g/mol), 49.7 mg gentamicin sulfate (AK 628) and 86.8 mg naproxen sodium salt (produced through the neutralization of naproxen (Fluka)) is ground up. 200 mg of this mixture, respectively, are pressed with a press at a pressure of 5 tons within a period of two minutes into disk-shaped molded bodies with a diameter of 13 mm.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07345024B2uspto-grants-2008_03