반응 #1478577

반응 방정식

4-fluoronitrobenzene

N-methyl-pyrrolidinone

N-(3-aminopropyl)pyrrolidine

K2CO3

→

N-(3-pyrrolidin-1-ylpropyl)-4-nitro-1-aminobenzene

수율 93.4%

용매

water

반응 조건

후처리

1. 1
   온도after cooling to room temperature
2. 2
   기타The yellow precipitate formed
3. 3
   여과was filtered off
4. 4
   건조dried over P2O5

실험 절차

2 g of 4-fluoronitrobenzene were added to a solution of 20 ml of N-methyl-pyrrolidinone, 2.18 g of N-(3-aminopropyl)pyrrolidine and 2.35 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 3.3 g of N-(3-pyrrolidin-1-ylpropyl)-4-nitro-1-aminobenzene (13) were obtained.

출처