반응 #1478575

반응 방정식

4-fluoronitrobenzene

N-methyl-pyrrolidine

N-(3-aminopropyl)-N′-methylpiperazine

K2CO3

→

N-[3-(4-methyl-piperazin-1-yl)propyl]-4-nitro-1-aminobenzene

수율 81.6%

N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene

수율 81.6%

용매

water

반응 조건

후처리

1. 1
   온도after cooling to room temperature
2. 2
   기타The yellow precipitate formed
3. 3
   여과was filtered off
4. 4
   건조dried over P2O5

실험 절차

2 g of 4-fluoronitrobenzene were added to a solution of 20 ml of N-methyl-pyrrolidine, 2.67 g of N-(3-aminopropyl)-N′-methylpiperazine and 2.35 g of K2CO3. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 3.22 g of N-[3-(4-methyl-piperazin-1-yl)propyl]-4-nitro-1-aminobenzene (9) were obtained.

출처