반응 #1472089

반응 방정식

2,4-dichloro-6,7,8-trimethoxyquinazoline

sodium hydride

methanol

→

title compound

수율 97.0%

2-Chloro-4,6,7,8-tetramethoxyquinazoline

수율 97.0%

반응 조건

후처리

1. 1
   온도The obtained mixture was heated
2. 2
   온도under reflux
3. 3
   workup.WAITAfter several hours
4. 4
   농축the reaction mixture was concentrated under a reduced pressure
5. 5
   workup.ADDITIONfollowed by the addition of water
6. 6
   기타The crystal thus precipitated
7. 7
   여과was recovered by filtration
8. 8
   세척washed with water
9. 9
   기타air-dried

실험 절차

5.00 g (17.3 mmol) of 2,4-dichloro-6,7,8-trimethoxyquinazoline was suspended in 100 ml of methanol, followed by the gradual addition of 1.5 g of sodium hydride. The obtained mixture was heated under reflux. After several hours, the reaction mixture was concentrated under a reduced pressure, followed by the addition of water. The crystal thus precipitated was recovered by filtration, washed with water and air-dried to give 4.80 g of the title compound as a pale-pink crystal.

출처