반응 #1470928

반응 방정식

γ-butyrolactone

ammonium chloride

1,1,1-tris(aminomethyl)ethane

→

amine

3-(aminomethyl)-3-methyl-2.3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine

용매

water

반응 조건

후처리

1. 1
   온도the mixture was cooled

실험 절차

A mixture of 21.03 g (0.24 mol) of γ-butyrolactone and 1.31 g (24 mmol) of ammonium chloride in 114.5 g (0.98 mol) of 1,1,1-tris(aminomethyl)ethane was heated at 250° C. in an autoclave. After 1.5 h, the mixture was cooled and the excess amine and the water formed were removed by distillation. The residue was distilled at 200°-240° C./18 mbar. The yield was 22.0 g (54%) of yellowish oil. The boiling point was 117°-120° C./1 mbar. Other data concerning the product was:

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