반응 #1470462
ord-dcf6d2501f0e499ab4b2d2766d1e0ee5
반응 방정식
potassium carbonate
6Z-16-bromohexadec-6-enoic acid
→
Z-oxacycloheptadec-7-en-2-one
수율 53.0%
반응 조건
온도
112.5°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타After usual work up 18 g of crude product were obtained
실험 절차
25 g of potassium carbonate were suspended in 300 ml of N-methyl pyrrolidone. 30 g (0.09 mol) of crude 6Z-16-bromohexadec-6-enoic acid in 200 ml of N-methyl- pyrrolidone were added dropwise while stirring at 110-115° C. within 10 hours. After usual work up 18 g of crude product were obtained, and after chromatography 12 g (53%) of Z-oxacycloheptadec-7-en-2-one were obtained having the following characteristics: Z/E=93/7;