반응 #1470461

ord-45b3a100f5c04085a552849f4fcc1e60

반응 방정식

O=C(O)CCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]
(5-carboxypentyl)triphenylphosphonium bromide
O=CCCCCCCCCCBr
10-bromodecanal
O=C(O)CCCC/C=C\CCCCCCCCCBr
6Z-16-bromohexadec-6-enoic acid
수율 65.0%

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

60 g (0.13 mol) of (5-carboxypentyl)triphenylphosphonium bromide were suspended in 250 ml of tetrahydrofuran. 30 g (0.26 mol) of potassium t-butylate in 20 ml of tetrahydrofuran were then added. Subsequently, 26 g (0/11 mol) of 10-bromodecanal were added. After usual work up 28 g (65%) of crude 6Z-16-bromohexadec-6-enoic acid were obtained having the following characteristics: Z/E=93/7;

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06255276B1uspto-grants-2001_07