반응 #1470460
ord-d809ceb78d584b6f8f6d8126318032d7
반응 방정식
(6-carboxyhexyl)triphenylphosphonium bromide
8-hydroxy-6-methyl-2-octanone
→
14-hydroxy-8,12-dimethyltetradec-7-enoic acid
수율 53.4%
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
95 g (0.2 mol) of (6-carboxyhexyl)triphenylphosphonium bromide in 600 ml of tetrahydrofuran were added to 48 g (0.42 mol) of potassium t-butylate in 200 ml of tetrahydrofuran. Thereafter, 29 g (0.18 mol) of 8-hydroxy-6-methyl-2-octanone were added. After work up and chromatography 26 g (48%) of 14-hydroxy-8,12-dimethyltetradec-7-enoic acid were obtained having the following characteristics: Z/E=58/42;