반응 #1470459

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Z-8-methyloxacyclopentadec-7-en-2-one

methanol

→

8-methyloxacyclopentadecan-1-one

수율 83.0%

반응 조건

후처리

1. 1
   기타hydrogenated (1.5 hours)
2. 2
   여과Then, the mixture was filtered over Celite
3. 3
   농축the solution was concentrated
4. 4
   workup.DISTILLATIONdistilled in a bulb-tube
5. 5
   기타chromatographed

실험 절차

25 g (0.10 mol) of Z-8-methyloxacyclopentadec-7-en-2-one were dissolved in 150 ml of methanol and hydrogenated (1.5 hours) with 2 g of 5% palladium-on-carbon with 100 mbar over-pressure. Then, the mixture was filtered over Celite, and the solution was concentrated, distilled in a bulb-tube and chromatographed. There were obtained 20 g (83%) of 8-methyloxacyclopentadecan-1-one were obtained having the following characteristics:

출처