반응 #1470458

반응 방정식

methyl 14-hydroxy-7-methyl-tetradec-6-enoate

potassium hydroxide

chloropropane- 1,2-diol

sodium methylate

→

8-methyloxacyclopentadec-7-en-2-one

수율 39.2%

용매

methanol

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe product was distilled (b.p. 114° C.) in a high vacuum (0.1 Torr)
2. 2
   기타subsequently chromatographed

실험 절차

84.5 g (0.31 mol) of methyl 14-hydroxy-7-methyl-tetradec-6-enoate, 21 g of 86 percent potassium hydroxide in 220 ml of methanol, 72 g of chloropropane- 1,2-diol and 9 ml of 5.4M methanolic sodium methylate solution were mixed according to the procedure in Example 6. The product was distilled (b.p. 114° C.) in a high vacuum (0.1 Torr) and subsequently chromatographed. 29 g (38%) of 8-methyloxacyclopentadec-7-en-2-one were obtained having the following characteristics, Z/E=60/40;

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