반응 #1470439

반응 방정식

Succinic anhydride

2,6-diisopropylphenol

→

2,6-diisopropylphenyl hydrogen succinate

수율 80.2%

용매

triethylamine

반응 조건

후처리

1. 1
   기타solvents were removed under vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   workup.ADDITIONadded to an iced solution of dilute hydrochloric acid
4. 4
   여과The precipitated product was filtered
5. 5
   기타recrystallized from ethanol-water

실험 절차

Succinic anhydride (14 g, 140 mmol) and dimethylaminopyridine (0.02 g, 0.16 mmol) were added to a solution of 2,6-diisopropylphenol (20.8 ml, 112 mmol) in triethylamine (50 ml) under nitrogen. After 16 hr at room temperature, solvents were removed under vacuum. The residue was dissolved in water and added to an iced solution of dilute hydrochloric acid. The precipitated product was filtered and recrystallized from ethanol-water to yield 25.0 g (80.2% yield) of 2,6-diisopropylphenyl hydrogen succinate (propofol hemisuccinate), mp 101-102° C.

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