반응 #1470438

반응 방정식

thionyl chloride

α-aminolauric acid

isopropanol

→

α-Aminolauric acid isopropyl ester

반응 조건

후처리

1. 1
   온도to reflux for two hours
2. 2
   온도After cooling off to room temperature
3. 3
   농축the batch is completely concentrated by evaporation
4. 4
   workup.STIRRINGshaken out from aqueous sodium carbonate solution
5. 5
   기타The organic phase is dried on magnesium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated by evaporation

실험 절차

50 ml of isopropanol is stirred at 0° C. under argon and mixed drop by drop with 3.12 ml (41.6 mmol) of thionyl chloride. 30 minutes later, 7.40 g (34.4 mmol) of α-aminolauric acid is added in portions, stirred for one hour at room temperature and the batch then is allowed to reflux for two hours. After cooling off to room temperature, the batch is completely concentrated by evaporation, the residue is taken up in tert-butyl methyl ether and shaken out from aqueous sodium carbonate solution. The organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

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