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8-benzyloxycarbonyl-2-dimethylamino-2,8-diazaspiro[4,5]decane-1,3-dione

hydrochloric acid

→

colorless crystal

2-Dimethylamino-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride

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후처리

1. 1
   기타The solvent was then evaporated
2. 2
   기타the resulting residual solid was recrystallized from ethanol-ethyl acetate

실험 절차

To the 8-benzyloxycarbonyl-2-dimethylamino-2,8-diazaspiro[4,5]decane-1,3-dione (0.4 g) which was obtained in Example 18 was added 6N hydrochloric acid (20 ml), and was followed by heating at 100° C. for 3 hours. The solvent was then evaporated; the resulting residual solid was recrystallized from ethanol-ethyl acetate to obtain 0.3 g of a colorless crystal having a melting point of from 257° to 260° C.

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