반응 #1465822

반응 방정식

NaHCO3

iodoacetyl chloride

5-Aminosalicylamide

HCl

→

5-(iodoacetamido)salicylamide

수율 96.0%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONis added dropwise over 15 min
2. 2
   기타The precipitate is collected
3. 3
   건조dried in vacuo over NaOH pellets

실험 절차

To an ice-cooled, stirred solution of 5-Aminosalicylamide (10.0 grams, 0.073 mol), in 300 mL of water containing NaHCO3 (42.0 grams, 0.5 mol), iodoacetyl chloride (18.4 grams, 0.09 mol) is added dropwise over 15 min. After stirring at 0°-5° C. for 1 hr., the solution is acidified with cold 6N HCl. The precipitate is collected and dried in vacuo over NaOH pellets, to afford 21.3 grams (96% yield) of crude 5-(iodoacetamido)salicylamide.

출처