반응 #1465697

반응 방정식

ethyl p-toluenesulfonate

1-piperidin-4-yl-1H-indole

potassium carbonate

→

1-(1-Ethyl-piperidin-4-yl)-1H-indole

용매

ethanol

반응 조건

후처리

1. 1
   온도The reaction was heated
2. 2
   온도under reflux for 24 hours
3. 3
   workup.STIRRINGwith stirring
4. 4
   기타quenched with water
5. 5
   추출extracted with methylene chloride (2×)
6. 6
   기타dried
7. 7
   기타evaporated
8. 8
   기타to give a residue
9. 9
   기타The residue was chromatographed on silica gel with toluene/acetone (50:50)
10. 10
    기타to yield 360 mg straw colored material (53% of theory)

실험 절차

To a solution of 1-piperidin-4-yl-1H-indole (0.6 g, 3 mmol) in 5 mL of dry ethanol was added anhydrous potassium carbonate (680 mg, 4.9 mmol). After stirring for 15 minutes at ambient temperature, ethyl p-toluenesulfonate (0.48 mL,4.5 mmol) was added. The reaction was heated under reflux for 24 hours with stirring, quenched with water, extracted with methylene chloride (2×), dried and evaporated to give a residue. The residue was chromatographed on silica gel with toluene/acetone (50:50) to yield 360 mg straw colored material (53% of theory).

출처